Chronopharmacology of intravenous and oral modified release verapamil

ISOPTIN SR (verapamil HCl) Sustained-Release Oral Tablets

DESCRIPTION ISOPTIN SR (verapamil hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). ISOPTIN SR is available for oral administration as light green, capsule shaped, scored, film-coated tablets containing 240 mg verapamil hydrochloride, as light pink, oval shaped, scored, film-coated tablets containing 180 mg verapamil hydrochloride, and as light v...

Release of motilin by oral and intravenous nutrients in man.

Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Individual food components either stimulated (oral fat) or suppressed release (or...

Effects of intravenous and chronic oral verapamil administration in patients with supraventricular tachyarrhythmias.

The efficacy of i.v. and oral verapamil was studied in 28 patients with supraventricular tachycardia (SVT). Verapamil (5-10 mg i.v.) terminated SVT in all six patients with atrioventricular nodal (AVN) reentrant tachycardia. In all patients verapamil prolonged antegrade but did not affect retrograde AVN conduction time. Two patients had associated sinus nodal reentrant tachycardia that persiste...

Guideline on quality of oral modified release products

Guideline on quality of oral modified release products

(Quality). Guideline on quality of oral modified release products